Extracting Dwell Time Sequences from Processive Molecular Motor Data
نویسندگان
چکیده
منابع مشابه
Extracting dwell time sequences from processive molecular motor data.
Processive molecular motors, such as kinesin, myosin, or dynein, convert chemical energy into mechanical energy by hydrolyzing ATP. The mechanical energy is used for moving in discrete steps along the cytoskeleton and carrying a molecular load. Single-molecule recordings of motor position along a substrate polymer appear as a stochastic staircase. Recordings of other single molecules, such as F...
متن کاملMaximum likelihood estimation of molecular motor kinetics from staircase dwell-time sequences.
Molecular motors, such as kinesin, myosin, or dynein, convert chemical energy into mechanical energy by hydrolyzing ATP. The mechanical energy is used for moving in discrete steps along the cytoskeleton and carrying a molecular load. High resolution single molecule recordings of motor steps appear as a stochastic sequence of dwells, resembling a staircase. Staircase data can also be obtained fr...
متن کاملDwell Time Distributions of the Molecular Motor Myosin V
The dwell times between two successive steps of the two-headed molecular motor myosin V are governed by non-exponential distributions. These distributions have been determined experimentally for various control parameters such as nucleotide concentrations and external load force. First, we use a simplified network representation to determine the dwell time distributions of myosin V, with the as...
متن کاملExtracting molecular Hamiltonian structure from time-dependent fluorescence intensity data
We propose a formalism for extracting molecular Hamiltonian structure from inversion of time-dependent fluorescence intensity data. The proposed method requires a minimum of a priori knowledge about the system and allows for extracting a complete set of information about the Hamiltonian for a pair of molecular electronic surfaces.
متن کاملMolecular linguistics: extracting information from gene and protein sequences.
Highly controversial only a few short years ago, the human genome project has spawned a vigorous new science called genomics. A decade ago a National Research Council (NRC) Report (1) came out with a compromise 15-year plan to produce comprehensive genetic and physical maps of the human genome, the sequence of the human genome and, surprisingly to many, the sequences of the genomes of a number ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2006
ISSN: 0006-3495
DOI: 10.1529/biophysj.105.079517